501 - Prediction of Mild Cognitive Impairment (MCI) progression to Alzheimer Disease (AD) or Dementia with Lewy Bodies (DLB): Is this possible neuropsychologically?

Objective: Aim of the present review study was to describe and compare neurocognitive features MCI which could predict its progression DLB vs AD. Background: Progression AD or is a relatively recent field with emphasis on clinical neuropsychological potentially specific types dementia. Methods: A literature in Pubmed database has been made, after year 2005, using key- words: assessment; MCI; AD; DLB; Seventeen relevant articles have found. Results: Data from most studies supports that, MCI, impairment executive, attentional visuospatial functions, as well letter fluency fluctuating concentration are mainly related DLB. In contrast, prominent episodic recognition memory deficits mostly found progresses Furthermore, non-amnestic often DLB, whereas amnestic type AD, although loss may not necessarily development Nevertheless, fewer suggest that MCI-DLB cognitive profile similar MCI-AD, while scoring alone does accurately MCI-AD. Interestingly, quantitative electroencephalogram help predicting preservation hippocampal volume associated increased risk especially MCI. Moreover, patterns neuroimaging contrast Conclusions: Predicting based profiles challenging useful for early therapeutic interventions. More needed, since there some conflicting findings and, at present, combination symptoms assessment ideal method prediction various